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Membrane localization of several lipidated proteins involved in cell signaling. Representative proteins from some of the major classes involved in signaling are shown. The attached lipids are color-coded: palmitoyl (S-acyl), red; myristoyl, blue; prenyl, purple; and unspecified acyl chains on GPI-linked proteins, green. EtN indicates ethanolamine. GPCR and NRTK refer to G protein-coupled receptors and nonrceptor tyrosine kinsases, respectively . The G protein alpha subunit, NRTK, and Ras proteins are shown with two lipids attached, although distinct isotypes of each protein may contain only one of the lipids. Appeared in Science. 268(5208):221-225,
14 April 1995. |
